1. The origin of this symbol is 1970s when it started being used in medical bulletins, prescriptions, and drug (medical) catalogues. There is no specific country of origin, but it's most likely to be Western, either European or American.
2. The symbol means danger for habituation, which is representative of amphetamines (drugs that stimulate the central nervous system) and drugs with the opposite effect, such as morphine, heroin and similar narcotics.
3. The symbol is both emotive and ambiguous. It stands for dangerous substances so when the symbol is detected it evokes a feeling of danger and warning and "keep out". It is also ambiguous since it is a symbol for two types of drugs that have opposite effects on the body.
4. Problems of knowledge include misunderstanding the meaning because of its ambiguity or not knowing the meaning at all and not realizing the hazardous significance of the drug.
Source:
http://www.symbols.com/encyclopedia/28/2816.html
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